So I never spend my AD time PLANNING to go to the airlines. I litaraly just got bored and had a friend applying to Skywest. When he showed up for his interview, I decided to go through class with him, so I applied. (Keep in mind that this is 2017 pre 'Rona). I was in class two weeks later. Here are things that I learned in the first six months, keeping in mind that I ignored all the airline talk in the squadron cuz I was gonna be retired and only half listened. All advice I am about to give is based on your stated preferences, which are remarkably similar to mine:
-Living in base is EVERYTHING. Commuting sucks. Don't do it unless you just can't stand living in one of the bases of your desired airline. I had to commute DEN to ORD for all of a month. After that, sitting reserve at home was awesome! Putz around the house with the phone on. NBD.
-Once I got a line, the advantage of a regional is that there are a lot of kids who are super hungry for hours, so I gave away enough trips a month to work 30-40 hours (8 ish days away) per month. That was also perfect for me. Working just enough to still enjoy it just became easier after COVID.
-Disadvantage is pay. Skywest starts out at $50/hour when a major airline doubles that. But, I was a Nav, so I didn't have the turbine time requirement to go straight to the "Majors". I think the same work schedule is possible at the Major Airlines fairly quickly, but I can't speak to it, I only have second hand knowledge, which is probobly the same as you have from the beat up old reserve LtCol who works for Southwest that you hang out with.
-Huge advantage is travel benifits. My wife and I have produced no crotch fruit and don't plan to. Kids out of the house is same thing. Wanna go hang in Hawaii for the weekend? The price is zero. Want a beer in Germany? $Free.95. You get the idea. We actually ran the calculations, and with my time off to free time ratio, we hit the road so much that the math said it trippled my paycheck in '19 in that benifit alone.
YMMV based on crash 9/11, crash of '08, 'Rona, Godzilla attack, etc. Bottom line is that I love it. Best part is going into work, getting on the jet, doing airplane things, and walking off with about 5 min of time spent on briefing/debriefing. You go to work to go FLY. The way God intended it. Appologies to anyone here for my threadjack, I hope it's good info.
Come stop by my airpark home with your fancy RV sometime. I'll provide the beer. 7CO0 is the airport ID just NW of KDEN.