I think this is the sticking point for a lot of the isolationists. They suggest we will demonstrably harm our economic interests by "taking sides," in this case, the side of defending sovereignty, but they forget that the very wealth they seek to protect was gained explicitly through the stability provided by a world that respects sovereignty.
You make it sound like there are only two choices, but obviously there are not. We aren't launching cruise missiles into Russia. There are many steps between unrestricted interaction and nuclear war. But we should not be supporting a country (and trading with the US is absolutely a form of support) that does not acknowledge sovereignty at a minimum.
We are also providing material support to the Ukrainians, which we should. We do this because we hope it will lead to a Russian failure, which would be a win for the concept of sovereignty.
The isolationists (FLEA being the most breathless example here. Similar to Tucker Carlson, who I also frequently agree with) keep asking what we are willing to sacrifice for Ukrainians. Not much, honestly. Ukrainians should sacrifice for Ukrainians, and they are. But for the geopolitical norm (sovereign borders) that has yielded unfathomable wealth and human flourishing for Americans and foreigners alike? Yes, for that we should sacrifice a lot.
And that concept of sovereignty came from the enlightenment-era moral revelation of the sovereignty of the individual. Turns out when you base your society around that morality, wealth and growth follow. We should not be so quick to let it wither.