"We" as in the military or the average American? For the average American, I don't think they really cared what happened in OEF. I doubt most of them even knew it was still going on. It wasn't the average American's resolve that lost OEF, it was bad leadership from the top (civilian and military) and lack of will from the Afghans.
Plenty of examples of wars popping off between trading partners in the history books.