Skip the .22, while I know that round can be as lethal as any other projectile; I am still a firm believer that there are better options out there.
Forget the revolvers aren't great concealed carry weapons especially for women. I know they are simpler and easier to resolve a misfire, but I think a woman who carries should carry a semi-auto and know the correct procedure to clear it if required. It's not that tough to rack a slide, I wouldn't make that an issue.
Instead, check out either a decent .380 (Ruger LCP or Taurus TCP, I prefer the latter) or a small-framed 9mm like the Taurus PT709 Slim. Or, if she's willing to try it, have her shoot a full-sized 9mm or even a .45 ACP. My wife recently shot a bunch of my pistols and ended up liking the XD-45 the best (well, after the TEC-9, which is a blast to shoot but makes for a horrible carry weapon!).
By the way, I agree with you on purse-carry; I don't like the idea but the wife is equally against carrying a pistol on her person. It's been an on-going debate between us and I have yet to convince her I am right (as usual).
Anyhow, best to try and get her to shoot several pistols and see what she prefers. Many ranges will rent them, or find some buds and see if they're willing to make a day of it at the range if you buy ammo and lunch!
Cheers! M2