That is an interesting question I've never considered. I'm really having trouble thinking of one. Only thing I can come up with is the scenario is that you like where you live, don't want to commute, and there is a regional domicile you can drive to, very quickly. That's about it. Even with that, regional contracts are at the whim of the majors they contract with, so that domicile could disappear at a moment's notice.
I agree with Social about travel benefits. You'd always have higher priority on your own metal anyway, if you wanted to travel beyond where your regional goes. If travel is your thing, there is a lot to be said for cargo, and getting miles for deadhead. ACMI for that matter. Or big picture, I make enough money that I can just buy the damn tickets.