I tried the same concept, but with a CMMG Banshee - also a roller delayed blowback. The recoil was much more uncomfortable than I expected. It just wasn't fun to shoot. (It was also totally unreliable suppressed, but that's immaterial since you didn't ask about the Banshee.)
I instead went with a 9" BCM 300BO pistol and a suppressor shooting 190gr subsonics and I'm mucho happier. The ballistics are effectively identical to 45 ACP at get-the-f-out-of-my-house ranges and it shoots oh so sweet. I also added a Superlative adjustable gas block that only made it that much sweeter with subs.
I love my 45 handguns. I'm waiting on a G30.5 right now. But for a rifle/pcc/subgun platform in this power category, 300BO is my hands down choice.